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|Methodology:||Chemiluminescent Immunoassay (CLIA)|
|Released:||24-48 hours after setup at PeaceHealth Laboratories’ reference lab.|
|Specimen Collection Details|
|Collection:||One 7.5 mL serum separator tube (SST). Also acceptable: green top tube (heparin).|
|Handling:||Allow to clot, centrifuge and separate serum from cells. Freeze. Critical frozen. If multiple tests are ordered, send separate specimen for this test.|
|Stability:||After separation from cells: 2 hours ambient or 3 months frozen. Specimen unstable refrigerated.|
|Standard Volume:||2 mL serum or plasma.|
|Minimum Volume:||1 mL serum or plasma.|
|Transport:||Frozen on dry ice.|
|Rejection Criteria:||EDTA plasma; gross hemolysis or lipemia.|
|Male 3 years and older||0.0-7.5 pg/mL|
|Female 3 years and older||0.0-5.1 pg/mL|
|Interpretive Data: Calcitonin levels greater than 100 pg/mL may occur in the following conditions: medullary thyroid carcinomas (MTC), leukemias, and myeloproliferative disorders.
Provocative testing (calcium) is suggested in patients with MTC if the calcitonin is not clearly diagnostic.
Calcitonin is useful in monitoring medullary thyroid carcinoma. The calcitonin assay value, regardless of level, should not be interpreted as absolute evidence of the presence or absence of malignant disease.
The Siemens Immulite® 2000 method is used. Results obtained with different assay methods or kits cannot be used interchangeably.