High Performance Liquid Chromatography/Tandem Mass Spectrometry (HPLC/MS/MS)
Edit Date:
11/16/2010
Performed:
Daily
Released:
24-48 hours after setup at PeaceHealth Laboratories’ reference lab.
CPT Code:
82492-90
Specimen Collection Details
Collection:
One 5 mL red top tube. Do not use separator tube (SST or PST). Also acceptable: One 4 mL green top tube (sodium heparin), 4 mL lavender top tube (EDTA), or 4 mL grey top tube (sodium fluoride/potassium oxalate).
Handling:
Allow to clot, centrifuge and separate serum or plasma from cells and pour into a plastic vial. Refrigerate.
Stability:
5 days ambient, 14 dyas refrigerated, or 6 months frozen.
Standard Volume:
2 mL serum or plasma.
Minimum Volume:
0.8 mL serum or plasma.
Transport:
Refrigerated.
Rejection Criteria:
Use of SST or PST.
Reference Range:
Total Clomipramine and Desmethyl:
220-500 ng/mL
Toxic:
>900 ng/mL
Plasma concentrations vary widely among patients. The therapeutic range listed relates to the antidepressant characteristics of the drug. A therapeutic range for treating obsessive-compulsive disorder is not well defined.