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82450:CLOMIPRAMINE (ANAFRANIL) and METABOLITE
Alias Names:Anafranil
Methodology:High Performance Liquid Chromatography/Tandem Mass Spectrometry (HPLC/MS/MS)
Edit Date:11/16/2010
Performed:Daily
Released:24-48 hours after setup at PeaceHealth Laboratories’ reference lab.
CPT Code:82492-90
Specimen Collection Details
Collection:One 5 mL red top tube. Do not use separator tube (SST or PST). Also acceptable: One 4 mL green top tube (sodium heparin), 4 mL lavender top tube (EDTA), or 4 mL grey top tube (sodium fluoride/potassium oxalate).
Handling:Allow to clot, centrifuge and separate serum or plasma from cells and pour into a plastic vial. Refrigerate.
Stability:5 days ambient, 14 dyas refrigerated, or 6 months frozen.
Standard Volume:2 mL serum or plasma.
Minimum Volume:0.8 mL serum or plasma.
Transport:Refrigerated.
Rejection Criteria:Use of SST or PST.
Reference Range:
Total Clomipramine and Desmethyl: 220-500 ng/mL
Toxic: >900 ng/mL
Plasma concentrations vary widely among patients. The therapeutic range listed relates to the antidepressant characteristics of the drug. A therapeutic range for treating obsessive-compulsive disorder is not well defined.