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| 69700:EPSTEIN-BARR VIRAL ANTIBODY PANEL 1 | |||||||||
| Alias Names: | EBV | ||||||||
| Methodology: | Mulltiplex flow immunoassay (Luminex) | ||||||||
| Edit Date: | 6/11/2010 | ||||||||
| Components: | Epstein-Barr Antibody, VCA, IgG / Epstein-Barr Antibody, VCA, IgM / EBV Interpretation | ||||||||
| Performed: | Daily | ||||||||
| Released: | Same day as tested | ||||||||
| CPT Code: | 86665 x2 | ||||||||
| Specimen Collection Details | |||||||||
| Collection: | One 7.5 mL serum separator tube (SST). Also acceptable: One 5 mL red top tube. | ||||||||
| Handling: | Allow to clot 10 minutes. Centrifuge and immediately separate serum from cells into a plastic vial. Refrigerate. Freeze at -20° C if specimen cannot be assayed within 7 days. Allow no more than three freeze/thaw cycles. | ||||||||
| Stability: | 8 hours ambient, 7 days refrigerated at 2-8° C, or 1 year frozen at -20° C. | ||||||||
| Standard Volume: | 1 mL serum. | ||||||||
| Minimum Volume: | 0.5 mL serum. | ||||||||
| Transport: | Refrigerated of received in laboratory within 7 days of collection, or frozen on dry ice. | ||||||||
| Rejection Criteria: | Plasma; gross lipemia; hemolysis; specimen that has been frozen/thawed more than 3 times; heat-inactivation; refrigerated specimen received in laboratory more than 7 days of collection, or ambient more than 8 hours of collection. | ||||||||
| EBV IgG Antibody to Viral Capsid Antigen (VCA) Result Interpretation, Luminex Method: | |||||||||||||||||||
| (AI = Antibody Index) | |||||||||||||||||||
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<0.8 AI
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Negative: No significant level of detectable IgG antibody to EBV Viral Capsid Antigen (VCA)
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0.9-1.0 AI
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Equivocal: Repeat testing in 10-14 days may be helpful
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≥ 1.1 AI
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Positive: IgG antibody to EBV Viral Capsid Antigen detected which may indicate a current or a previous
EBV infection |
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| EBV IgM Antibody to Viral Capsid Antigen (VCA) Result Interpretation, EIA Method: | |||||||||||||||||||
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<0.8 AI
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Negative: No significant level of detectable IgM antibody to EBV Viral Capsid Antigen (VCA)
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0.9-1.0 AI
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Equivocal: Repeat testing in 10-14 days may be helpful
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≥ 1.1 AI
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Positive: IgM antibody to EBV Viral Capsid Antigen (VCA) detected which may indicate a current or recent
EBV infection |
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| IV = Index Value | |||||||||||||||||||
| Clinical Stage | Susceptible | Very Early Infection | Current/Recent Infection | Past Infection | |||||||||||||||
| VCA – IgM | – | +/- | + | – | |||||||||||||||
| VCA – IgG | – | +/- | + | + | |||||||||||||||
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+/- means positive or negative |
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