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Alias Names: Anti-Dnase B Antibody / Group A, Streptococcus
Methodology: Nepelometry (NEPH)
Edit Date: 9/17/2007
Performed: Tuesday, Thursday, Saturday
Released: 2-4 days after setup at PeaceHealth Laboratories’ reference lab.
CPT Code: 86215-90
Specimen Collection Details
Collection: One 7.5 mL serum separator tube (SST).
Handling: Allow to clot. Centrifuge, separate serum from cells and immediately pour into a plastic vial.
Stability: 48 hours ambient, 14 days refrigerated, or 1 year frozen.
Standard Volume: 1 mL serum.
Minimum Volume: 0.5 mL serum.
Transport: Refrigerated.
Comments: The majority of group A streptococci produce significant quantities of DNase-B, while most other groups of streptococci do not. High levels of neutralizing antibody to DNase-B are commonly found in patients following a group A streptococcal infection. Since it persists longer than other streptococcal antibodies (2-3months), it is the preferred test in patients with chorea suspected to be due to rheumatic fever. Since it is not influenced by the site of infection, DNase-B antibody is more reliable than the streptolysin O antibody (ASO) test in providing evidence for streptococcal infection in patients with post-impetigo glomerulonephritis. Elevated titers are strongly suggestive of recent or current infection with group A streptococci. Fourfold increases in titer between acute and convalescent samples taken approximately 2 weeks apart are confirmatory.
Rejection Criteria: Plasma or severly hemolyzed samples.

1-6 years 0-70 U/mL
7-17 years 0-170 U/mL
18 years and older 0-120 U/mL

PeaceHealth Laboratories