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| 80640:AMIODARONE & METABOLITE | |||||||||
| Alias Names: | Cordarone | ||||||||
| Methodology: | High Performance Liquid Chromatography (HPLC) | ||||||||
| Edit Date: | 6/11/2010 | ||||||||
| Performed: | Sunday-Friday | ||||||||
| Released: | 24-72 hours after setup at PeaceHealth Laboratories’ reference lab. | ||||||||
| CPT Code: | 80299-90 x2 | ||||||||
| Specimen Collection Details | |||||||||
| Collection: | One 5 mL red top tube. Also acceptable: One 4 mL green top tube (sodium heparin), lone 4 mL lavendar top tube (EDTA), or one 4 mL grey top tube (sodium fluoride/potassium oxalate). Do not use serum separator tube (SST) or plasma separator tube (PST). | ||||||||
| Handling: | Protect from light. Allow to clot, centrifuge and separate serum or plasma from cells. Refrigerate. | ||||||||
| Stability: | Specimen stable 4 weeks ambient, 6 weeks refrigerated, or 6 weeks frozen. | ||||||||
| Standard Volume: | 2 mL serum or plasma. | ||||||||
| Minimum Volume: | 0.8 mL serum or plasma. | ||||||||
| Transport: | Refrigerated. | ||||||||
| Rejection Criteria: | Use of serum separator tube (SST), (PST), or gels. | ||||||||
| Amoidarone | 1.0-3.0 ug/mL | ||||||||||||||||||
| Desethylamoidarone | Not established | ||||||||||||||||||
| Potential toxic level | >3.0 ug/mL | ||||||||||||||||||
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Interpretative Data: The therapeutic range of amiodarone is not presently well established. Toxic effects may begin above 3.0 ug/mL. The concentration of desethylamiodarone, a major metabolite, is also reported, but no therapeutic range is available. At steady-state, the metabolite concentration is similar to the amiodarone concentration. This metabolite may be pharmacologically active, but the extent of activity is not known with certainty. |
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