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| 69250:SMOOTH MUSCLE ANTIBODY | |||||||||
| Alias Names: | ANTI-SMOOTH MUSCLE ANTIBODY | ||||||||
| Methodology: | Enzyme-Linked Immunosorbent Assay (ELISA) | ||||||||
| Edit Date: | 4/1/2005 | ||||||||
| Performed: | Thursday | ||||||||
| Released: | Same day as tested | ||||||||
| CPT Code: | 83516 | ||||||||
| Specimen Collection Details | |||||||||
| Collection: | One 7.5 mL serum separator tube (SST). Also acceptable: One 5 mL red top tube. | ||||||||
| Handling: | Allow to clot 10 minutes. Centrifuge and separate serum from cells immediately and pour into a plastic vial. Refrigerate until transported. Freeze at -20° C if specimen cannot be assayed within 5 days. Avoid repeated freeze/thaw cycles. | ||||||||
| Standard Volume: | 1 mL serum. | ||||||||
| Minimum Volume: | 100 µL serum. | ||||||||
| Transport: | Refrigerated; or if frozen, on dry ice. | ||||||||
| Rejection Criteria: | Plasma; gross lipemia; hemolysis; contaminated specimen. | ||||||||
| Smooth Muscle antibody, IgG Result Interpretation ELISA Method: | |||||||||||||||||||
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<20.0 EU (EU=ELISA Unit) |
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| <20.0 EU | 20.0-30.0 EU | >30.0 EU | |||||||||||||||||
| Negative: No Smooth Muscle antibody (ASMA) detected. | Weak Positive: Repeat testing may be helpful. | Positive: Smooth Muscle, IgG antibody (ASMA) detected. | |||||||||||||||||
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Anti-actin autoantibodies are the main component of what have been called Smooth Muscle antibodies (ASMA). ASMA are found in 52-95% of patients with autoimmune hepatitis (AIH) or chronic active hepatitis (CAH) and in 22% of patients with primary bilary cirrhosis (PBC). ASMA have been reported, usually in low titers, in 3-18% of sera from the general healthy population. |
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