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Alias Names: ANNA / Anti-Neuronal Nuclear Ab
Methodology: Western Blot (WB)
Edit Date: 6/11/2010
Performed: Tuesday, Friday
Released: 1-4 days after setup at PeaceHealth Laboratories’ reference lab.
CPT Code: 84181-90
Specimen Collection Details
Collection: One 7.5 mL serum separator tube (SST).
Handling: Allow to clot, centrifuge and separate serum from cells into a plastic vial.
Stability: 7 days ambient, 14 days refrigerated, or 2 months frozen.
Standard Volume: 2 mL serum.
Minimum Volume: 1 mL serum.
Transport: Refrigerated.
Comments: CNS paraneoplastic syndromes (neurological disorders which occur as a remote effect of a cancer) are generally thought to be the result of an autoimmune process in which autoantibodies to antigens expressed in tumor tissue are directed against similar antigens of the central nervous system. Neuronal nuclear autoantibodies (Type 1 ANNA; also know as ANNA-1 and Hu autoantibodies) are found in a number of paraneoplastic syndromes, including sub acute sensory neuropathy (SSN), paraneoplastic cerebellar degeneration (PCD), and are associated with small-cell lung cancer.
Rejection Criteria: Plasma.

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