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Alias Names: CCP
Methodology: Enzyme-Linked Immunosorbent Assay (ELISA)
Edit Date: 4/19/2010
Performed: Tuesday, Friday
Released: Same day as tested
CPT Code: 86200
Specimen Collection Details
Collection: One 7.5 mL serum separator tube (SST). Also acceptable: One 5 mL red top tube.
Handling: Allow to clot, centrifuge and immediately separate serum from cells into a plastic vial. Store refrigerated until transport. Freeze at -20° C if the specimen cannot be assayed within 48 hours. Avoid repeated freeze/thaw cycles.
Standard Volume: 1 mL serum.
Minimum Volume: 0.4 mL serum
Transport: Refrigerated if received at laboratory within 48 hours of collection, or frozen on dry ice.
Rejection Criteria: Hyperlipemic, hemolytic, heat-treated or contaminated specimen; secimen containing visible particulate should not be used; specimen subjected to repeated freeze/thaw cycles; refrigerated specimen received in laboratory more than 48 hours after collection.

Cyclic Citrullinated Peptide (CCP), IgG Interpretation, ELISA method:

<20 Eu (EU=Enzyme Units)

<20 EU Negative
20-39 EU Weak Positive
40-59 EU Moderate Positive
>=60 EU Strong Positive

Approximately 70% of patients with Rheumatoid Arthritis are positive for CCP, IgG, while only 2% of random blood donors and disease controls are positive. The diagnostic value of antibodies to CCP in juvenile Rheumatoid Arthitis patients has not been determined.

PeaceHealth Laboratories