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|80455:5-HYDROXYINDOLEACETIC ACID (HIAA), URINE|
|Alias Names:||5-HIAA / Serotonin Metabolite, Urine|
|Methodology:||High Performance Liquid Chromatography (HPLC)|
|Released:||24-72 hours after setup at PeaceHealth Laboratories’ reference lab.|
|Specimen Collection Details|
|Collection:||24-hour or random urine. Refrigerate during collection, storage and transport. Patients should abstain, if possible, from medications, over-the-counter drugs, and herbal remedies for at least 72 hours prior to the test. 24-hour collection is generally recommended, but random collection may be used. Refrigeration is the most important aspect of specimen preservation.|
|Handling:||5 mL aliquot from a well-mixed urine collection. Record total volume and collection time interval on transport tube and requisition. Refrigerate.|
|Stability:||7 days refrigerated or 14 days frozen. Specimen unstable ambient.|
|Standard Volume:||5 mL urine.|
|Minimum Volume:||1 mL urine.|
|Comments:||5-Hydroxyindoleacetic acid (5-HIAA) results are expressed as a ratio to creatinine excretion (mg/ g crt). HIAA mass per day (mg/d) is not reported if the urine collection is random, other than a 24-hour, or for a urine volume less than 400 mL/d.
Foods and medications associated with altered urinary HIAA results:
Decreased HIAA: Aspirin, chlorpromazine (Thorazine), corticotropin, dihydroxyphenylacetic acid, ethanol, gentisic acid, homogentisic acid, hydrazine derivatives, imipramine (Tofranil®), isocarboxazid (Marplan), keto acids, levodopa, MAO inhibitors, methenamine, methyldopa (Aldometperchlorperazine, phenothiazines (Compazine®), promazine, promethazine (Mepergan®).
Increased HIAA: Acetaminophen, acetanilide, caffeine, coumaric acid, diazepam (Valium®), ephedrine, fluorouracil, glycerol guaiacolate (Guaifenesin), melphalan (Alkeran®), mephenesin, methamphetamine (Desoxyn), methocarbamol (Robaxin®), naproxen, nicotine, phenacetin, phenmetrazine, phenobarbital, phentolamine, rauwolfia, reserpine.
Foods: Avocados, bananas, eggplant, pineapple, plums, tomatoes, walnuts.
Foods rich in serotonin and medications which may affect metabolism of serotonin must be avoided at least 72 hours before and during collection of urine for HIAA.
|5-HIAA, Urine||0.0-15.0 mg/d|
0-14 mg/g crt
The HIAA-to-creatinine ration
will be reported whenever the urine
collection is random
or other than 24-hour,
or the urine volume is less than
400 mL/24 hours.
|3-8 years||140-700 mg/d||140-700 mg/d|
|9-12 years||300-1300 mg/d||300-1300 mg/d|
|13-17 years||500-2300 mg/d||400-1600 mg/d|
|18-50 years||1000-2500 mg/d||700-1600 mg/d|
|51-80 years||800-2100 mg/d||500-1400 mg/d|
|81 years and older||600-2000 mg/d||400-1300 mg/d|