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| 80455:5-HYDROXYINDOLEACETIC ACID (HIAA), URINE | |||||||||
| Alias Names: | 5-HIAA / Serotonin Metabolite, Urine | ||||||||
| Methodology: | High Performance Liquid Chromatography (HPLC) | ||||||||
| Edit Date: | 6/11/2010 | ||||||||
| Performed: | Sunday, Tuesday-Saturday | ||||||||
| Released: | 24-72 hours after setup at PeaceHealth Laboratories’ reference lab. | ||||||||
| CPT Code: | 83497-90 | ||||||||
| Specimen Collection Details | |||||||||
| Collection: | 24-hour or random urine. Refrigerate during collection, storage and transport. Patients should abstain, if possible, from medications, over-the-counter drugs, and herbal remedies for at least 72 hours prior to the test. 24-hour collection is generally recommended, but random collection may be used. Refrigeration is the most important aspect of specimen preservation. | ||||||||
| Handling: | 5 mL aliquot from a well-mixed urine collection. Record total volume and collection time interval on transport tube and requisition. Refrigerate. | ||||||||
| Stability: | 7 days refrigerated or 14 days frozen. Specimen unstable ambient. | ||||||||
| Standard Volume: | 5 mL urine. | ||||||||
| Minimum Volume: | 1 mL urine. | ||||||||
| Transport: | Refrigerated. | ||||||||
| Comments: | 5-Hydroxyindoleacetic acid (5-HIAA) results are expressed as a ratio to creatinine excretion (mg/ g crt). HIAA mass per day (mg/d) is not reported if the urine collection is random, other than a 24-hour, or for a urine volume less than 400 mL/d.
Foods and medications associated with altered urinary HIAA results: Decreased HIAA: Aspirin, chlorpromazine (Thorazine), corticotropin, dihydroxyphenylacetic acid, ethanol, gentisic acid, homogentisic acid, hydrazine derivatives, imipramine (Tofranil®), isocarboxazid (Marplan), keto acids, levodopa, MAO inhibitors, methenamine, methyldopa (Aldometperchlorperazine, phenothiazines (Compazine®), promazine, promethazine (Mepergan®). Increased HIAA: Acetaminophen, acetanilide, caffeine, coumaric acid, diazepam (Valium®), ephedrine, fluorouracil, glycerol guaiacolate (Guaifenesin), melphalan (Alkeran®), mephenesin, methamphetamine (Desoxyn), methocarbamol (Robaxin®), naproxen, nicotine, phenacetin, phenmetrazine, phenobarbital, phentolamine, rauwolfia, reserpine. Foods: Avocados, bananas, eggplant, pineapple, plums, tomatoes, walnuts. Foods rich in serotonin and medications which may affect metabolism of serotonin must be avoided at least 72 hours before and during collection of urine for HIAA. |
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| Reference Inteval | |||||||||||||||||||
| Components | Reference Interval | ||||||||||||||||||
| 5-HIAA, Urine | 0.0-15.0 mg/d | ||||||||||||||||||
| 5-HIAA, Urine |
0-14 mg/g crt
The HIAA-to-creatinine ration will be reported whenever the urine collection is random or other than 24-hour, or the urine volume is less than 400 mL/24 hours. |
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| Creatinine (24-hour) | Male | Female | |||||||||||||||||
| 3-8 years | 140-700 mg/d | 140-700 mg/d | |||||||||||||||||
| 9-12 years | 300-1300 mg/d | 300-1300 mg/d | |||||||||||||||||
| 13-17 years | 500-2300 mg/d | 400-1600 mg/d | |||||||||||||||||
| 18-50 years | 1000-2500 mg/d | 700-1600 mg/d | |||||||||||||||||
| 51-80 years | 800-2100 mg/d | 500-1400 mg/d | |||||||||||||||||
| 81 years and older | 600-2000 mg/d | 400-1300 mg/d | |||||||||||||||||