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| 87745:ALDOSTERONE/RENIN ACTIVITY RATIO | |||||||||
| Methodology: | Radioimmunoassay (RIA) | ||||||||
| Edit Date: | 8/6/2009 | ||||||||
| Performed: | Daily | ||||||||
| Released: | 1-5 days after setup at PeaceHealth Laboratories’ reference lab. | ||||||||
| CPT Code: | 82088-90 / 84244-90 | ||||||||
| Specimen Collection Details | |||||||||
| Collection: | Order only if request is for “Activity Ratio.” Two tubes total: One 7.5 mL serum separator tube (SST), and one 4 mL lavender top tube (EDTA). |
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| Handling: | Centrifuge and separate serum and plasma from cells immediately. Freeze. Critical frozen. If multiple tests are ordered, send separate specimens for this test. | ||||||||
| Stability: | After separation from cells: 4 hours ambient or 30 days frozen. Unstable refrigerated. | ||||||||
| Standard Volume: | 1 mL serum and 1 mL plasma | ||||||||
| Minimum Volume: | 0.6 mL serum and 0.6 mL plasma. | ||||||||
| Transport: | Frozen on dry ice. | ||||||||
| Rejection Criteria: | Refrigerated plasma. | ||||||||
| Reference Range: | |||||||||||||||||||
| Components | Reference Interval | ||||||||||||||||||
| Aldosterone, Serum | Age | Posture Unspecified | Supine | Upright | |||||||||||||||
| 0-6 days | 5.0-102.0 ng/dL | ||||||||||||||||||
| 1-3 weeks | 6.0-179.0 ng/dL | ||||||||||||||||||
| 1-11 months | 7.0-99.0 ng/dL | ||||||||||||||||||
| 1-2 years | 7.0-93.0 ng/dL | ||||||||||||||||||
| 3-10 years | 4.0-44.0 ng/dL | ||||||||||||||||||
| 11-14 years | 4.0-31.0 ng/dL | ||||||||||||||||||
| 11-14 years | 4.0-31.0 ng/dL | ||||||||||||||||||
| 15 years and older | 31.0 ng/dL or less | 16.0 ng/dL or less | 4.0-31.0 ng/dL | ||||||||||||||||
| Renin Activity | Adult, normal sodium diet: | ||||||||||||||||||
| Supine: 0.2-1.6 ng/mL/hr | |||||||||||||||||||
| Upright: 0.5-4.0 ng/mL/hr | |||||||||||||||||||
| Newborn (1-7 days): 2.0-35.0 ng/mL/hr | |||||||||||||||||||
| Cord blood: 4.0-32.0 ng/mL/hr | |||||||||||||||||||
| Children, normal sodium diet, supine: | |||||||||||||||||||
| 1-12 months: 2.4-37.0 ng/mL/hr | |||||||||||||||||||
| 13 months-3 years: 1.7-11.2 ng/mL/hr | |||||||||||||||||||
| 4-5 years: 1.0-6.5 ng/mL/hr | |||||||||||||||||||
| 6-10 years: 0.5-5.9 ng/mL/hr | |||||||||||||||||||
| 11-15 years: 0.5-3.3 ng/mL/hr | |||||||||||||||||||
| AldosterCalculation one/Renin Activity | < 25 | ||||||||||||||||||
| An Aldosterone/Renin Activity Ratio >25 is suggestive of hyperaldosteronism. | |||||||||||||||||||