80635:SACCHAROMYCES CEREVISIAE ANTIBODIES IgG & IgA

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80635:SACCHAROMYCES CEREVISIAE ANTIBODIES IgG & IgA
Methodology: Enzyme-Linked Immunosorbent Assay (ELISA)
Edit Date: 11/17/2010
Performed: Daily
Released: 24-48 hours after setup at PeaceHealth Laboratories’ reference lab
CPT Code: 86671-90 x2
Specimen Collection Details
Collection: One 7.5 mL serum separator tube (SST).
Handling: Allow to clot, centrifuge and separate serum from cells immediately and pour into a plastic vial . Refrigerate.
Stability: 48 hours ambient, 14 days refrigerated, or 1 year frozen. Allow no more than one freeze/thaw cycle.
Standard Volume: 0.5 mL serum
Minimum Volume: 300 µL serum
Transport: Refrigerated.
Comments: This test may be a useful tool for distinguishing ulcerative colitis (UC) from Crohn disease (CD) in patients with suspected inflammatory bowel disease.
Rejection Criteria: Severely lipemic, contaminated, heat-inactivated, or hemolyzed specimen.

Referene Range:
COMPONENTS
REFERENCE INTERVAL
Saccharomyces cerevisiae Antibody, IgA
≤ 20.0 Units: Negative
20.1-24.9 Units: Equivocal
≥ 25.0 Units: Positive
Saccharomyces cerevisiae Antibody, IgG
≤ 20.0 Units: Negative
20.1-24.9 Units: Equivocal
≥ 25.0 Units: Positive
Interpretive Data: Saccharomyces cerevisiae IgG antibodies are found in 60-70% of Crohn disease (CD) patients and 10-15% of ulcerative colitis (UC) patients. Saccharomyces cerevisiae IgA antibodies are found in about 35% of CD patients but less than 1% in UC patients. Detection of both Saccharomyces IgG and IgA antibodies in the same serum specimen is highly specific for CD.

PeaceHealth Laboratories