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| 80635:SACCHAROMYCES CEREVISIAE ANTIBODIES IgG & IgA | |||||||||
| Methodology: | Enzyme-Linked Immunosorbent Assay (ELISA) | ||||||||
| Edit Date: | 11/17/2010 | ||||||||
| Performed: | Daily | ||||||||
| Released: | 24-48 hours after setup at PeaceHealth Laboratories’ reference lab | ||||||||
| CPT Code: | 86671-90 x2 | ||||||||
| Specimen Collection Details | |||||||||
| Collection: | One 7.5 mL serum separator tube (SST). | ||||||||
| Handling: | Allow to clot, centrifuge and separate serum from cells immediately and pour into a plastic vial . Refrigerate. | ||||||||
| Stability: | 48 hours ambient, 14 days refrigerated, or 1 year frozen. Allow no more than one freeze/thaw cycle. | ||||||||
| Standard Volume: | 0.5 mL serum | ||||||||
| Minimum Volume: | 300 µL serum | ||||||||
| Transport: | Refrigerated. | ||||||||
| Comments: | This test may be a useful tool for distinguishing ulcerative colitis (UC) from Crohn disease (CD) in patients with suspected inflammatory bowel disease. | ||||||||
| Rejection Criteria: | Severely lipemic, contaminated, heat-inactivated, or hemolyzed specimen. | ||||||||
| Referene Range: | |||||||||||||||||||
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COMPONENTS
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REFERENCE INTERVAL
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Saccharomyces cerevisiae Antibody, IgA
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≤ 20.0 Units: Negative
20.1-24.9 Units: Equivocal
≥ 25.0 Units: Positive
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Saccharomyces cerevisiae Antibody, IgG
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≤ 20.0 Units: Negative
20.1-24.9 Units: Equivocal
≥ 25.0 Units: Positive
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| Interpretive Data: Saccharomyces cerevisiae IgG antibodies are found in 60-70% of Crohn disease (CD) patients and 10-15% of ulcerative colitis (UC) patients. Saccharomyces cerevisiae IgA antibodies are found in about 35% of CD patients but less than 1% in UC patients. Detection of both Saccharomyces IgG and IgA antibodies in the same serum specimen is highly specific for CD. | |||||||||||||||||||