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Methodology: Methylation
Edit Date: 2/2/2009
Performed: Varies
Released: 14 days after setup at PeaceHealth Laboratories’ reference lab.
CPT Code: 83891-905E / 83892-905E / 83894-905E / 83912-905E
Specimen Collection Details
Collection: CHILD: One 4 mL lavender top tube (EDTA). ADULT: Two 4 mL lavender top tube (EDTA). Also acceptable: One 8.5 mL yellow top tube (ACD-A)
Handling: Do not spin. Send as whole blood. Include diagnostic indications for testing.
Stability: 7 days ambient or 7 days refrigerated. Unstable frozen.
Standard Volume: CHILD: 4 mL whole blood. ADULT: 8 mL whole blood.
Minimum Volume: 4 mL whole blood (child or adult).
Transport: Ambient.
Comments: Prader-Willi syndrome (PWS) is characterized by hypotonia, failure to thrive in infancy, rapid weight gain/obesity between 12 months and 6 years, characteristics of PWS, or pregnancies at risk due to a known translocation or imprinting mutation.
Angelman syndrome (AS) is characterized by severe developmental delay/mental retardation, absence of speech, ataxic gait, inappropriate laughter, hand-flapping, and less frequently, microcephaly, and seizures. Indications for testing include clinical characteristics of AS or pregnancies at risk due to a known translocation or imprinting mutation. AS is not usually suspected in the first year of life, but becomes a consideration between 1-4 years of age.
Rejection Criteria: Frozen specimen, broken specimen tubes; clotted specimen. Specimen other than those specified above.
This test may require insurance company prior authorization before ordering.
Please check the prior authorization list
Failure to gain preauthorization may result in denial of coverage.

PeaceHealth Laboratories