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|85690:MANGANESE (Mn), 24-HOUR URINE|
|Methodology:||Inductively Coupled Plasma/Mass Spectrometry (ICP/MS)|
|Released:||1-5 days after setup at PeaceHealth Laboratories’ reference lab.|
|Specimen Collection Details|
|Collection:||24-hour or random urine in a plastic container. Refrigerate during collection, storage, and transportation.|
|Handling:||Record total volume and collection time on requisition form. Mix well and aliquot into two ARUP Trace Element-free transport tubes, available from Client Services.|
|Stability:||7 days ambient, 14 days refrigerated, or 1 year frozen.
Studies indicate that the refrigeration alone of urine during and after collection preserves specimen adequately, if tested within 14 days of collection.
|Standard Volume:||10 mL urine aliquot|
|Minimum Volume:||5 mL urine aliquot|
|Comments:||Useful for detecting toxic manganese exposure. Urine analysis is useful as a screening test for significant exposure and for calculating clearance following exposure. Usual daily intake is 1-10 mg/day, but <5% is absorbed). Fecal excretion is the primary route of elimination. Iron deficiency anemia will cause increased absorption, with associated increased urinary excretion.
Contamination of urine is easy since the usual daily excretion rate is low and manganese-containing dust is common. Trace contamination of acid preservatives used for stabilizing the urine has also been observed. Interpretation: The normal manganese excretion is <2.0 µg/24 hours. Individuals with significant exposure will excrete >10 µg/24 hours. Manganism presents as a Parkinsonian-like disease, but usually in individuals much younger than 60 years of age.
The normal value is for a 24-hour collection. Specimens collected for other than a 24-hour time period are reported in units of µg/L, for which normal values are not established.
|Rejection Criteria:||Urine collected within 48 hours after administration of a gadolinium (Gd) containing contrast media (may occur with MRI studies); acid preserved urine.|
|Manganese, Urine||0.0-2.0 µg/L|
|Manganese, Urine (24-hour)||0.0-2.0 µg/d|
|Manganese per gram of creatinine||No reference interval (µg/g crt)|
|3-8 years: 140-700 mg/d||3-8 years: 140-700 mg/d|
|9-12 years: 300-1300 mg/d||9-12 years: 300-1300 mg/d|
|13-17 years: 500-2300 mg/d||13-17 years: 400-1600 mg/d|
|18-50 years: 1000-2500 mg/d||18-50 years: 700-1600 mg/d|
|51-80 years: 800-2100 mg/d||51-80 years: 500-1400 mg/d|
|81 years and older: 600-2000 mg/d||81 years and older: 400-1300 mg/d|