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Methodology: Indirect Fluorescent Antibody (IFA) (IFA/IMAGE) / Farr Radiobinding Assay (RBA) / Enzyme Immunoassay (EIA/LIA) / Immunochromatographic Membrane Assay (ICMA) / Turbidimetry
Edit Date: 10/8/2009 12:55:24 PM
Components: Antinuclear Antibodies (ANA) / ANA Pattern / dsDNA Autoantibodies (Native) / nRNP/Sm IgG Autoantibodies (U1-RNP/snRNP) / SS-A (Ro) IgG Autoantibodies / SS-B (La) IgG Autoantibodies / Sm (Smith) IgG Autoantibodies / Scl-70 IgG Autoantibodies / Ribosomal P Protein Autoantibodies / Thyroid Peroxidase Autoantibodies / C3 Complement / C4 Complement / Rheumatoid Factor, IgM
Performed: Daily
Released: 24-48 hours after setup at PeaceHealth Laboratories’ reference lab. If ANA is positive, panel will be completed; if ANA is negative, testing will end.
CPT Code: 86038-90
Specimen Collection Details
Collection: One 7.5 mL serum separator tube (SST).
Handling: Centrifuge and separate serum into a plastic vial. Refrigerate.
Stability: 48 hours ambient, 7 days refrigerated, or 2 months frozen.
Standard Volume: 4 mL serum.
Minimum Volume: 2 mL serum.
Transport: Refrigerated.
Comments: This panel is used to aid in the screening and diagnosis of autoimmune disorders such as Mixed Connective Tissue Diseases, Systemic Lupus Erythematosus, Sjogren’s Syndrome, CREST syndrome (calcinosis, Raynaud’s syndrome, esophageal dysfunction, sclerodactyly and telangiectasia), Idiopathic Raynaud’s Syndrome, drug induced lupus, diffuse scleroderma, etc., also including autoimmune thyroiditis, rheumatoid arthritis, and atypical autoimmune disorders. Individual components are also available.
Rejection Criteria: Lipemic and moderately or grossly icteric and hemolyzed specimen.

Reference Range:
Antinuclear Antibodies (ANA) < 7.5 IU/mL
ANA Pattern By Report
dsDNA Autoantibodies < 5.0 IU/mL
nRNP/Sm IgG Autoantibodies < 5.0 Units
SS-A IgG Autoantibodies < 5.0 Units
SS-B IgG Autoantibodies < 5.0 Units
Sm (Smith) IgG Autoantibodies < 5.0 Units
Scl-70 IgG Autoantibodies < 5.0 Units
Ribosomal P Protein Autoantibodies < 5.0 Units
Thyroid Peroxidase Autoantibodies < 60 U/mL
C3 Complement 90 – 180 mg/dL
C4 Complement 16 – 47 mg/dL
Rheumatoid Factor < 14 IU/mL

PeaceHealth Laboratories