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|Methodology:||Agarose Electrophoresis (AE) / Inspection (Insp) / Nephelometry (NEPH)|
|Components:||Cryoglobulin 72 hours / Cryoglobulin 7 days / Cryoprecipitate IgG / Cryoprecipitate IgM / Cryoprecipitate IgA / Cryoprecipitate RF / IFE on Cryoprecipitate|
|Released:||7 days after setup at PeaceHealth Laboratories reference lab|
|Specimen Collection Details|
|Collection:||Two 5 mL red top tubes which have been pre-warmed to 37° C. Patient must be fasting. NOTE: Do not collect on a Friday.|
|Handling:||Immediately after collection, incubate red top tube at 37° C for one hour. Centrifuge and, maintaining at 37° C, separate serum into a plastic vial, labeled as serum. Specimen can now be held ambient. Do not refrigerate or freeze.|
|Stability:||72 hours ambient. Unstable refrigerated or frozen.|
|Standard Volume:||5 mL serum.|
|Minimum Volume:||3 mL serum.|
|Comments:||If cryoglobulin is present, Cryoprecipitate is tested for IgG, IgM, IgA, RF and IFE for an additional fee. Add 2 to 4 days to turnaround time.
Cryoglobulins may be present in macroglobulinemia of Waldenstrom, myeloma, chronic lymphocytic leukemia, lupus, chronic active hepatitis, and other viral infections.
|Rejection Criteria:||Specimen not incubated at 37° C for one hour or maintained at 37° C during collection process; refrigerated or frozen specimen.|