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|84660:HOMOVANILLIC ACID (HVA), 24-HOUR URINE|
|Alias Names:||3-Methoxy-4-Hydroxy Phenylacetic Acid|
|Methodology:||High Performance Liquid Chromatography (HPLC)|
|Released:||24-72 hours after setup at Peacehealth Laboratories’ reference lab.|
|Specimen Collection Details|
|Collection:||24-hour urine in a plastic urine container. Refrigerate during collection, storage, and transport.|
|Handling:||Mix well and aliquot into a plastic container. Note total volume and collection time interval on tube and test requisition.|
|Stability:||7 days refrigerated or 14 days frozen. Unstable ambient.|
|Standard Volume:||5 mL aliquot.|
|Minimum Volume:||3 mL aliquot.|
|Rejection Criteria:||Ambient specimen.|
|HVA, Urine||18 years and older||0.0-15.0 mg/d|
ratio will be reported when
the patient is under 18 years,
the urine collection is
random or other than 24 hours,
or the urine volume is
less than 400 mL/24 hours.
|HVA, Urine||0-2 years||0-42 mg/g crt|
|3-5 years||0-22 mg/g crt|
|6-17 years||0-15 mg/g crt|
|18 years and older||0-8 mg/g crt|
|3-8 years||140-700 mg/d||140-700 mg/d|
|9-12 years||300-1300 mg/d||300-1300 mg/d|
|13-17 years||500-2300 mg/d||400-1600 mg/d|
|18-50 years||1000-2500 mg/d||700-1600 mg/d|
|51-80 years||800-2100 mg/d||500-1400 mg/d|
|81 years and older||600-2000 mg/d||400-1300 mg/d|
|Homovanillic acid (HVA) results are expressed as a ratio to creatinine excretion (mg/g cr). HVA mass per day (mg/d) is not reported on specimens from patients younger than 18 years of age, for random specimens, urine collection periods other than 24 hours, or for urine volumes less than 400 mL/d.
Moderately elevated HVA (homovanillic acid) may be caused by a variety of factors such as essential hypertension, intense anxiety, intense physical exercise, and numerous drug interactions (including some over-the-counter medications and herbal products).
Medications which may interfere with catecholamines and their metabolites include amphetamines and amphetamine-like compounds, appetite suppressants, bromocriptine, buspirone, caffeine, chlorpromazine, clonidine, disulfiram, diuretics (in doses sufficient to deplete sodium), epinephrine, glucagon, guanethidine, histamine, hydrazine derivatives, imipramine, levodopa (L-dopa, Sinemet®), lithium, MAO inhibitors, melatonin, methyldopa (Aldomet®), morphine, nitroglycerin, nose drops, propafenone (Rythmol), radiographic agents, rauwolfia alkaloids (Reserpine), and vasodilators. The effects of some drugs on catecholamine metabolite results may not be predictable.