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| 58459:HERPES SIMPLEX VIRUS (HSV) 1 and 2 GLYCOPROTEIN G-SPECIFIC, IgG | |||||||||
| Methodology: | Multiplex flow immunoassay (Luminex) | ||||||||
| Edit Date: | 4/19/2010 | ||||||||
| Performed: | Daily | ||||||||
| Released: | Same day as tested | ||||||||
| CPT Code: | 86695 / 86696 | ||||||||
| Specimen Collection Details | |||||||||
| Collection: | One 7.5 mL serum separator tube (SST). Also acceptable: One 5 mL red top tube. | ||||||||
| Handling: | Allow to clot10 minutes, centrifuge and immediately separate serum from cells into a plastic vial. Refrigerate. Freeze at -20° C if specimen cannot be assayed within 7 days . Allow no more than three freeze/thaw cycles. If multiple tests are ordered, send separate specimen for this test. | ||||||||
| Standard Volume: | 1 mL serum. | ||||||||
| Minimum Volume: | 0.5 mL serum. | ||||||||
| Transport: | Refrigerated, or frozen on dry ice. | ||||||||
| Rejection Criteria: | Plasma; grossly contaminated, hemolyzed, lipemic, heat-inactivated, or icteric specimen; specimen received in laboratory ambient more than 8 hours or refrigerated more than 7 days after collection; specimen frozen and thawed more than three times. | ||||||||
| Reference Range: <0.90 AI (Antibody Index) | |||||||||||||||||||
| <0.90 AI |
Negative: No significant level of detectable IgG antibody to HSV type 1 glycoprotein G.
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| 0.90-1.10 AI |
Equivocal: Questionable presence of IgG antibody to HSV type 1. Repeat testing in 10-14 days may be helpful.
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| >1.10 AI |
Positive: IgG antibody to HSV type 1 glycoprotein G detected, which may indicate a current or recent HSV infection.
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| <0.90 AI |
Negative: No significant level of detectable IgG antibody to HSV type 2 glycoprotein G.
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| 0.90-1.10 AI |
Equivocal: Questionable presence of IgG antibody to HSV type 2. Repeat testing in 10-14 days may be helpful.
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| >1.10 AI |
Positive: IgG antibody to HSV type 2 glycoprotein G detected, which may indicate a current or recent HSV infection.
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| Individuals infected with HSV may not exhibit detectable IgG antibody to glycoprotein G in the early stages of infection and 5-10% of infections may occur with glycoprotein G deficient virus. Detection of antibody presence in these cases may only be possible using a non type-specific screening test. | |||||||||||||||||||