24-72 hours after setup at PeaceHealth Laboratories’ reference lab
CPT Code:
85306 Free / 85305 Total if appropriate
Specimen Collection Details
Collection:
One 4.5 light blue top tube (sodium citrate).
Handling:
Immediately centrifuge and plasma. Centrifuge again and separate into TWO plastic vials, each containing 0.5 mL plasma. Do not use glass vials. NOTE: A double-centrifuged specimen is critical for accurate results as platelet contamination may cause spurious results. Label each tube as ‘double-spun plasma.’ Freeze immediately ≤ -40° C. Indicate if patient is on Coumadin, which will lower Protein S. Each coagulation assay requested should have its own vial.
Standard Volume:
1 mL plasma divided into two tubes containing 0.5 mL each.
Minimum Volume:
0.5 mL plasma divided into two tubes (may result in QNS for reflex testing)
Transport:
Frozen on dry ice.
Comments:
Useful for investigation of patients with a history of thrombosis.
Rejection Criteria:
Thawing or thawed specimen; hemolysis or lipemia.
Reference Range:
TOTAL
Male
80-160%
Female <50 years
70-160%
Female ≥50 years
80-160%
FREE
Male
65-160%
Female <50 years
50-160%
Female ≥50 years
65-160%
Protein S values vary widely in the normal population and are age- and sex-dependent.
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