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Edit Date: 4/6/2010
Performed: Varies
Released: 7-10 days after setup at PeaceHealth Laboratories’ reference lab
CPT Code: 86235-90
Specimen Collection Details
Collection: One 7.5 mL serum separator tube (SST).
Handling: Allow to clot, centrifuge and separate serum to a plastic vial. Refrigerate.
Standard Volume: 2 mL serum
Minimum Volume: 2 mL serum
Transport: Refrigerated.
Comments: Extractable nuclear antibodies (precipitating antibodies) have definitive diagnostic information. Precipitating antibodies to soluble tissue antigens are present in diverse rheumatic diseases: anti-Sm is highly specific for SLE; anti-nRNP (nuclear ribonucleoprotein) is present in SLE and overlap syndromes with scleroderma and polymyosities; anti=Scl-70 is highly specific for scleroderma; anti-Ro and anti-La are associated with SLE and Sjogren’s syndrome; anti-P is a new specificity related to psychosis in SLE patients as well as patients with nephritis and unexplained hepatitis; anti-Jo-1, anti-PM-Scl and anti-Mi-2 may be seen in polymyositis patients.

PeaceHealth Laboratories