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88235:KAPPA LAMBDA LIGHT CHAIN, RANDOM URINE
Methodology:Nephelometry (NEPH)
Edit Date:10/30/2010
Components:Kappa Light Chain / Lambda Light Chain
Performed:Monday-Friday
Released:24-72 hours after setup at PeaceHealth Laboratories' reference lab
CPT Code:83883-90 x2
Specimen Collection Details
Collection:Random urine in a clean container. Do not add preservatives.
Handling:Refrigerate. Indicate on requisition that collection is random.
Stability:9 days refrigerated. Unstable ambient or frozen.
Standard Volume:2 mL random urine
Minimum Volume:0.5 mL random urine
Transport:Refrigerated.
Comments:Approximately 50% of multiple myeloma patients excrete free light chains in urine. About half of such patients excrete free light chains only; whereas, the other half excrete free light chains and the corresponding intact immunoglobulin. Light chain excretion is roughly proportional to tumor burden with more advanced disease and can be useful in monitoring therapy.
Reference Range:
Kappa Light Chain <1.9 mg/dL
Lambda Light Chain <5.0 mg/dL