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Methodology:Nephelometry (NEPH) / Calculation (CALC)
Edit Date:11/3/2010
Released:24-72 hours after setup at PeaceHealth Laboratories' reference lab
CPT Code:83883-90
Specimen Collection Details
Collection:24-hour urine in a clean, dry, plastic container. Refrigerate during collection, storage, and transport. NOTE: Patient should discard the first morning urine (e.g., 7:00 a.m.) and collect all subsequent urine including the first void of the second morning (e.g., 7:00 a.m.).
Handling:Aliquot 10 mL urine from a well-mixed collection. Refrigerate. Record total volume on specimen and requisition.
Stability:9 days refrigerated. Unstable ambient or frozen.
Standard Volume:10 ml urine
Minimum Volume:0.5 mL urine
Comments:Approximately 50% of multiple myeloma patients excrete free light chains in urine. About half of such patients excrete free light chains only; whereas, the other half excrete free light chains and the corresponding intact immunoglobulin. Light chain excretion is roughly proportional to tumor burden with more advanced disease and can be useful in monitoring therapy. See also Myeloma EvaluatR (serum free light chains).