85680:MANGANESE (Mn)

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85680:MANGANESE (Mn)
Methodology: Inductively Coupled Plasma/Mass Spectrometry (ICP/MS)
Edit Date: 6/11/2010
Performed: Tuesday, Friday
Released: 1-5 days after setup at PeaceHealth Laboratories’ reference lab.
CPT Code: 83785-90
Specimen Collection Details
Collection: One 6 mL royal blue top tube trace element serum tube.

Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, nonessential over-the-counter medications (upon the advice of their physician).

Handling: Allow to clot, centrifuge and separate serum from cells and immediately pour into either an ARUP Trace Element-Free transport tube, available from PeaceHealth Laboratories Client Services, or a royal blue trace element-no additive tube. Do not allow serum to remain on cells. Refrigerate.
Stability: If the specimen is drawn and stored in the appropriate container, the trace element values do not change with time.
Standard Volume: 2 mL serum.
Minimum Volume: 0.5 mL serum.
Transport: Refrigerated.
Comments: This test is useful for detecting toxic manganese exposure.

Less than 5% of manganese present in circulation resides in the serum.

Rejection Criteria: Use of any tube other than specified; specimen clotted or not separated from cells; hemolysis.

Reference Range:
0.0-2.0 µg/L
Manganese is ubiquitous in our environment. Manganese contributes to the color of red brick, is present in most steel alloys as an anti-corrosive, is used extensively in laboratories as a cleaning agent for glassware, and is a common pigment in paints and glazes. Humans exhibit toxicity to manganese when exposed to large quantities of dust containing manganese such as in mining, ore-crushing, during machining of alloys, and the dust from construction and destruction of brick. Manganese accumulates in the substantia nigra of the brain, causing a Parkinson-like syndrome in humans after chronic exposure.

Normal manganese in human serum ranges from 0.3-0.9 ng/mL. Individuals with significant exposure to manganese who display toxicity excrete milligram quantities of manganese per day and have serum levels in excess of 100 ng/mL. Most of the manganese in our daily diet is not absorbed and passes through the gastrointestinal tract.

PeaceHealth Laboratories