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|Methodology:||Inductively Coupled Plasma/Mass Spectrometry (ICP/MS)|
|Released:||1-5 days after setup at PeaceHealth Laboratories’ reference lab.|
|Specimen Collection Details|
|Collection:||One 6 mL royal blue top tube trace element serum tube.
Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, nonessential over-the-counter medications (upon the advice of their physician).
|Handling:||Allow to clot, centrifuge and separate serum from cells and immediately pour into either an ARUP Trace Element-Free transport tube, available from PeaceHealth Laboratories Client Services, or a royal blue trace element-no additive tube. Do not allow serum to remain on cells. Refrigerate.|
|Stability:||If the specimen is drawn and stored in the appropriate container, the trace element values do not change with time.|
|Standard Volume:||2 mL serum.|
|Minimum Volume:||0.5 mL serum.|
|Comments:||This test is useful for detecting toxic manganese exposure.
Less than 5% of manganese present in circulation resides in the serum.
|Rejection Criteria:||Use of any tube other than specified; specimen clotted or not separated from cells; hemolysis.|
|Manganese is ubiquitous in our environment. Manganese contributes to the color of red brick, is present in most steel alloys as an anti-corrosive, is used extensively in laboratories as a cleaning agent for glassware, and is a common pigment in paints and glazes. Humans exhibit toxicity to manganese when exposed to large quantities of dust containing manganese such as in mining, ore-crushing, during machining of alloys, and the dust from construction and destruction of brick. Manganese accumulates in the substantia nigra of the brain, causing a Parkinson-like syndrome in humans after chronic exposure.
Normal manganese in human serum ranges from 0.3-0.9 ng/mL. Individuals with significant exposure to manganese who display toxicity excrete milligram quantities of manganese per day and have serum levels in excess of 100 ng/mL. Most of the manganese in our daily diet is not absorbed and passes through the gastrointestinal tract.