88420:TETANUS ANTIBODY, IgG

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88420:TETANUS ANTIBODY, IgG
Methodology: Multi-Analyte Fluorescent Detection.
Edit Date: 6/11/2010
Performed: Monday-Friday.
Released: 1-4 days after setup at PeaceHealth Laboratories’ reference lab.
CPT Code: 86317-90
Specimen Collection Details
Collection: One 7.5 mL serum separator tube (SST).
Handling: Allow to clot, centrifuge and separate serum from cells and pour into a plastic vial. Refrigerate.
Stability: 48 hours ambient, 14 days refrigerated, or 1 year frozen. Avoid repeated freeze/thaw cycles.
Standard Volume: 1 mL serum.
Minimum Volume: 200 µL serum.
Transport: Refrigerated.
Rejection Criteria: Plasma; other body fluids; severely lipemic, contaminated, or hemolyzed specimen.

Interpretiave Data:
Responder status is determined according to the ratio of a one-month post-vaccination sample to pre-vaccination concentration of Tetanus IgG Antibodies as follows:

1. If the post-vaccination concentration is less than 1.0 IU, the patient is considered a nonresponder.

2. If the post-vaccination concentration is greater than or equal to 1.0 IU, the patient with a ratio of less than 1.5 is a nonresponder, a ratio 1.5 to less than 3.0, a weak responder, and a ratio of 3.0 or greater, a good responder.

3. If the pre-vaccination concentration is less than 1.0, it may be difficult to assess the response based on a ratio alone. A post-vaccination concentration greater than 2.5 IU in this case is usually adequate.

Antibody concentration of >0.1 UI/mL is usually considered protective.

PeaceHealth Laboratories