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|88420:TETANUS ANTIBODY, IgG|
|Methodology:||Multi-Analyte Fluorescent Detection.|
|Released:||1-4 days after setup at PeaceHealth Laboratories’ reference lab.|
|Specimen Collection Details|
|Collection:||One 7.5 mL serum separator tube (SST).|
|Handling:||Allow to clot, centrifuge and separate serum from cells and pour into a plastic vial. Refrigerate.|
|Stability:||48 hours ambient, 14 days refrigerated, or 1 year frozen. Avoid repeated freeze/thaw cycles.|
|Standard Volume:||1 mL serum.|
|Minimum Volume:||200 µL serum.|
|Rejection Criteria:||Plasma; other body fluids; severely lipemic, contaminated, or hemolyzed specimen.|
| Responder status is determined according to the ratio of a one-month post-vaccination sample to pre-vaccination concentration of Tetanus IgG Antibodies as follows:
1. If the post-vaccination concentration is less than 1.0 IU, the patient is considered a nonresponder.
2. If the post-vaccination concentration is greater than or equal to 1.0 IU, the patient with a ratio of less than 1.5 is a nonresponder, a ratio 1.5 to less than 3.0, a weak responder, and a ratio of 3.0 or greater, a good responder.
3. If the pre-vaccination concentration is less than 1.0, it may be difficult to assess the response based on a ratio alone. A post-vaccination concentration greater than 2.5 IU in this case is usually adequate.
|Antibody concentration of >0.1 UI/mL is usually considered protective.|