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| 88420:TETANUS ANTIBODY, IgG | |||||||||
| Methodology: | Multi-Analyte Fluorescent Detection. | ||||||||
| Edit Date: | 6/11/2010 | ||||||||
| Performed: | Monday-Friday. | ||||||||
| Released: | 1-4 days after setup at PeaceHealth Laboratories’ reference lab. | ||||||||
| CPT Code: | 86317-90 | ||||||||
| Specimen Collection Details | |||||||||
| Collection: | One 7.5 mL serum separator tube (SST). | ||||||||
| Handling: | Allow to clot, centrifuge and separate serum from cells and pour into a plastic vial. Refrigerate. | ||||||||
| Stability: | 48 hours ambient, 14 days refrigerated, or 1 year frozen. Avoid repeated freeze/thaw cycles. | ||||||||
| Standard Volume: | 1 mL serum. | ||||||||
| Minimum Volume: | 200 µL serum. | ||||||||
| Transport: | Refrigerated. | ||||||||
| Rejection Criteria: | Plasma; other body fluids; severely lipemic, contaminated, or hemolyzed specimen. | ||||||||
| Interpretiave Data: | |||||||||||||||||||
| Responder status is determined according to the ratio of a one-month post-vaccination sample to pre-vaccination concentration of Tetanus IgG Antibodies as follows:
1. If the post-vaccination concentration is less than 1.0 IU, the patient is considered a nonresponder. 2. If the post-vaccination concentration is greater than or equal to 1.0 IU, the patient with a ratio of less than 1.5 is a nonresponder, a ratio 1.5 to less than 3.0, a weak responder, and a ratio of 3.0 or greater, a good responder. 3. If the pre-vaccination concentration is less than 1.0, it may be difficult to assess the response based on a ratio alone. A post-vaccination concentration greater than 2.5 IU in this case is usually adequate. |
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| Antibody concentration of >0.1 UI/mL is usually considered protective. | |||||||||||||||||||