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Methodology: Chemiluminescence (CL)
Edit Date: 4/18/2010
Performed: Daily
Released: Same day as tested
CPT Code: 86778
Specimen Collection Details
Collection: One 7.5 mL serum separator tube (SST). Also acceptable: 5 mL red top tube.
Handling: Allow to clot, centrifuge and separate serum from cells within 2 hours. Refrigerate. Freeze if specimen cannot be assayed within 48 hours. Allow no more than three freeze/thaw cycles.
Stability: 48 hours refrigrated.
Standard Volume: 0.5 mL serum.
Minimum Volume: 150 µL serum.
Transport: Refrigerated; or if frozen, on dry ice.
Comments: Toxoplasma IgM antibody testing can be used to verify early infections. Toxoplasmosis, caused y the parasite Toxoplasma gondii, can cause serious congenital abnormalities following maternal infections just prior to or during pregnancy. It is also common in persons known to have AIDS or who are otherwise immuno-compromised.

See also: Torch Antibodies, IgM (58941) and Torch Antibodies, IgG & IgM (58961).

Rejection Criteria: Gross hemolysis; gross lipemia; heat inactivation; bacterial contamination; specimen frozen and thawed more than three times.

Reference Range:
S/Co = Sample to Cut-off Ratio
≤ 0.89 S/Co Negative: Non-reactive for IgM antibody to Toxoplasma gondii.
0.90-1.09 S/Co Equivocal: Repeat testing in 10-14 days may be helpful.
≥ 1.10 S/Co Positive: Reactive for IgM antibody to Toxoplasma gondii.
While the presence of IgM antibodies suggests current or recent infection, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection. Caution should be exercised in the use of IgM antibody levels in prenatal screening. Any positive results should be confirmed with amniocentesis and PCR testing for Toxoplasma gondii.

PeaceHealth Laboratories