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Alias Names: Transferrin Receptor Level
Methodology: Immunoturbidimetric
Edit Date: 6/11/2010
Performed: Daily
Released: 24-48 hours after setup at PeaceHealth Laboratories’ reference lab.
CPT Code: 84238-90
Specimen Collection Details
Collection: One 7.5 mL serum separator tube (SST). Also acceptable: One 4 mL green top tube (heparin).
Handling: Allow to clot, centrifuge and separate serum or plasma from cells within 30 minutes. Freeze. Allow no more than three freeze/thaw cycles.
Stability: 3 days ambient, 7 days refrigerated, 1 month frozen at -20° C or 1 year frozen at -70° C.
Standard Volume: 1 mL serum or plasma.
Minimum Volume: 300 µL serum or plasma.
Transport: Frozen on dry ice.
Rejection Criteria: Hemolyzed, icteric, lipemic or contaminated specimen; specimen frozen and thawed more than three times.

Reference Range
Male – 18 years and older 2.2-5.0 mg/L
Female – 18 years and older 1.9-4.4 mg/L
People of African descent and those residing at 5,200 feet above sea level were found to have a 6% higher normal value. These differences were additive. No reference values have been established for pregnant females, subjects under 18 years of age, and recent or frequent blood donors.

Serum soluble transferrin receptor increases in iron deficiency and is usually unaffected by chronic disease states. In general, to increase sensitivity and specificity, the measurement of serum soluble transferrin receptor should be performed in combination with other tests of iron status, including ferritin, TIBC and serum iron (refer to table below).

Tests for Changes in: Iron Deficiency Anemia Anemia of Chronic Disease Iron Deficiency & Anemia of Chronic Disease
Ferritin Iron Stores Low High Normal or High
TIBC Iron Status High Low Normal or High
Serum Iron Iron Status Low Low Low
sTfR Iron Status High Normal High

PeaceHealth Laboratories