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Alias Names: MMA
Methodology: Tandem Mass Spectrometry (MS/MS)
Edit Date: 6/11/2010
Performed: Daily
Released: 48 hours after setup at PeaceHealth Laboratories’ reference lab.
CPT Code: 83921-90
Specimen Collection Details
Collection: 5 mL random urine or 24-hour urine. 24-hour urine should be refrigerated during collection, storage, and transport.
Handling: Freeze urine in a clean, dry plastic container. Label specimen as urine. Record total volume and collection time interval on tube and on requisition.
Stability: Specimen stable 4 days refrigerated or 1 month frozen. Specimen unstable ambient.
Standard Volume: 5 mL urine.
Minimum Volume: 0.5 mL urine.
Transport: Frozen on dry ice.
Comments: B12 injection will interfere with testing.

Elevated urinary methylmalonic acid is an early and sensitive indicator of vitamin B12 (cobalamin) deficiency.

This test can also be used to monitor patients with methylmalonic aciduria. Diagnosis of methylmalonic aciduria requires an organic acid panel and appropriate clinical history.

Rejection Criteria: Ambient or thawing specimen.

Mathylmalonic Acid, Urine Creatinine (24-hour)
0.0-3.6 nmol/mol CRT By reports (reports may vary based on instrumentation)

PeaceHealth Laboratories