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Alias Names: Anti-Histone Ab / Drug Induced SLE
Methodology: Enzyme-Linked Immunosorbent Assay (ELISA)
Edit Date: 11/16/2010
Performed: Monday, Wednesday-Saturday
Released: 1-3 days after setup at PeaceHealth Laboratories’ reference lab
CPT Code: 86235-90
Specimen Collection Details
Collection: One 7.5 mL serum separator tube (SST).
Handling: Allow to clot, centrifuge and immediately separate serum from cells into a plastic vial. Refrigerate.
Stability: 48 hours ambient, 14 days refrigerated, or 1 year frozen. Avoid repeated freeze/thaw cycles.
Standard Volume: 1 mL serum.
Minimum Volume: 0.3 mL serum.
Transport: Refrigerated.
Comments: Histone antibodies are present in 20-55% of idiopathic systemic lupus erythematosus (SLE) and 80-95% of drug-induced SLE. They occur in less than 20% of other types of connective tissue diseases.
Rejection Criteria: Plasma; severe lipemia; bacterial contamination; hemolysis.

Reference Range:
<1.0 Units None detected
1.0-1.5 Units Inconclusive
1.6-2.5 Units Positive
>2.5 Units Strong Positive

PeaceHealth Laboratories