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Alias Names: Lupus Analyzer / Analyzer Panel
Methodology: Indirect Fluorescent Antibody/Image Analysis (IFA/IMAGE) / Indirect Fluorescent Antibody (IFA) / Farr Radiobinding Assay (Farr RBA) / Enzyme Immunoassay (EIA) / Immunochemiluminometric Assay (ICMA) / Latex Immunoassay (LIA) / Turbidometric Assay (TURB)
Edit Date: 10/27/2008
Components: Antinuclear Antibodies (Int’l Units and Patterns) / dsDNA Autoantibodies / nRNP/Sm(Smith) Antibodies, IgG / Sm (Smith) IgG Autoantibodies / SS-A IgG Autoantibodies / SS-B IgG Autoantibodies / Scl-70 IgG Auntoantibodies / Thyroid Peroxidase Autoantibodies / C3 Complement / C4 Complement / Rheumatoid Factor IgM Autoantibodies / Ribosomal P Protein Autoantibodies
Performed: Tuesday-Saturday
Released: 1-4 days after setup at PeaceHealth Laboratories’ reference lab. 5 days for confirmation of positives.
CPT Code: 83516-90 / 86038-90 / 86160-90 x2 / 86225-90 / 86235-90 x5 / 86376-90 / 86431-90
Specimen Collection Details
Collection: One 7.5 mL serum separator tube (SST).
Handling: Allow to clot, centrifuge and separate serum from cells and pour into a plastic vial. Refrigerate.
Stability: 48 hours ambient, 7 days refrigerated, or 30 days frozen.
Standard Volume: 4 mL serum.
Minimum Volume: 2 mL serum.
Transport: Refrigerated.
Rejection Criteria: Plasma; lipemic, moderately or grossly icteric, and hemolyzed specimens are not suitable for analysis. Specimen requirements must be met to prevent a QNS result.

Reference Range:
This panel is used to aid in the screening and diagnosis of autoimmune disorders such as Mixed Connective Tissue Diseases, Systemic Lupus Erythematosus, Sjogren Syndrome, CREST syndrome (calcinosis, Raynaud’s syndrome, esophageal dysfunction, sclerodactyly and telangiectasia), Idiopathic Raynaud’s Syndrome, drug induced lupus, ANA-negative lupus, diffuse scleroderma, etc., also including autoimmune thyroiditis, rheumatoid arthritis, and atypical autoimmune disorders. Individual components are also available.
Result Name Method Reference Range
Antinuclear Antibodies (ANA) IFA/IMAGE <7.5 IU/mL
ANA Pattern IFA By Report
dsDNA Autoantibodies Farr RBA <5.0 IU/mL
nRNP/Sm(Smith) IgG Autoantibodies EIA/LIA <5.0 IU/mL
Sm (Smith) IgG Autoantibodies EIA/LIA <5.0 IU/mL
SS-A IgG Autoantibodies EIA/LIA <5.0 IU/mL
SS-B IgG Autoantibodies EIA/LIA <5.0 IU/mL
Scl-70 IgG Autoantibodies EIA/LIA <5.0 IU/mL
Ribosomal P Protein Autoantibodies EIA/LIA <5.0 IU/mL
Thyroid Peroxidase Autoantibodies ICMA <60 U/mL
C3 Complement TURB 90-180 mg/dL
C4 Complement TURB 16-47 mg/dL
Rheumatoid Factor IgM Autoantibodies TUUB <14 IU/mL

PeaceHealth Laboratories