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Methodology: See Individual Components
Edit Date: 2/18/2008
Components: Hepatitis B Core Antibody Total, IgG and IgM (Anti-HBc Total) / Hepatitis B Surface Antibody (Anti-HBs) / Hepatitis B Surface Antigen (HBsAG) / Hepatitis Be Antibody (Anti-HBe), if indicated / Hepatitis Be Antigen (HBeAG), if indicated / Hepatitis B Core Antibody, IgM (Anti-HBc, IgM), if indicated / NOTE: Hepatitis Be Antibody / Hepatitis Be Antigen / Hepatitis B Core Antibody, IgM will be performed and charged, if indicated. While these tests reflect our recommendations for testing, all tests included in this panel may be ordered individually or in any combination.
Performed: Tuesday-Saturday
Released: Same day as tested
CPT Code: 86704 / 86706 / 87340 / (86707 if indicated) / (87350 if indicated) / (86705 if indicated)
Specimen Collection Details
Collection: One 7.5 mL serum separator tube (SST). Also acceptable: One 5 mL red top tube. Patients need not be fasting and no special preparations are necessary.
Handling: Allow to clot, centrifuge and separate serum from cells immediately. Refrigerate. Freeze if specimen will not be assay within 48 hours. Allow no more than two freeze/thaw cycles. If other testing is ordered, send separate specimen for this test.
Standard Volume: 3 mL serum.
Minimum Volume: 2 mL serum.
Transport: Refrigerated if received in laboratory within 48 hours of collection, or frozon on dry ice.
Comments: Useful for:
1) Evaluating patients with suspected or confirmed chronic hepatitis B,
2) Monitoring hepatitis B viral infectivity,
3) Follow-up testing for patients with acute hepatitis B.
Rejection Criteria: Gross hemolysis; gross lipemia; heat-inactivated specimens; refrigerated specimen received in laboratory more than 48 hours after collection.

Reference Range:
See individual components.
Hepatitis Chronic B Panel Interpretation:
HBsAG Anti-HBc Anti-HBs Anti-HBc IgM Anti-HBe HBeAG Interpretation
+ + + Chronic Type B Hepatitis, infectious state, (consider ordering HBV-DNA)
+ + + Chronic Type B Hepatitis, carrier state
+ + + not done not done Acute Type B Hepatitis
+ not done not done Past Type B Hepatitis infection, no evidence of immunity
+ + not done not done Past Type B Hepatitis infection with immunity
+ not done not done not done Past Hepatitis B or immunization with immunity

PeaceHealth Laboratories