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Methodology: See Individual Components
Edit Date: 11/14/2009
Components: Hepatitis B Core Antibody Total, IgG and IgM (Anti-HBc, Total) / Hepatitis B Surface Antibody (Anti-HBs) / Hepatitis B Surface Antigen (HBsAG) / Hepatitis C Virus Antibody (HCV) / Hepatitis B Core Antibody, IgM (Anti-HBc, IgM), if indicated / Hepatitis Be Antibody (Anti-HBe), if indicated / Hepatitis Be Antigen (HBeAG), if indicated. NOTE: Hepatitis B Core Antibody, IgM, Hepatitis Be Antibody, Hepatitis Be Antigen will be performed and charged if indicated. While these tests reflect our recommendations for testing, all tests included in this panel may be ordered individually or in any combination.
Performed: Daily
Released: Same day as tested
CPT Code: 86803 / 87340 / 86704 / 86706
Specimen Collection Details
Collection: One 7.5 mL serum separator tube (SST). Also acceptable: One 5 mL red top tube. Patients need not be fasting and no special preparations are necessary.
Handling: Allow to clot, centrifuge and immediately separate serum from cells. Refrigerate. Freeze if specimen cannot be assayed within 48 hours. Avoid repeated freeze/thaw cycles. If other testing will be ordered, send a separate specimen for this test.
Standard Volume: 3 mL serum.
Minimum Volume: 2 mL serum.
Transport: Refrigerated if received in laboratory within 48 hours of collection, or frozen on dry ice.
Comments: Useful for diagnosis and evaluation of patients with symptoms of hepatitis with duration greater than 6 months, and distinguishing between chronic hepatitis B and chronic hepatitis C.
Rejection Criteria: Gross hemolysis; gross lipemia; heat-inactivated specimens; refrigerated specimen received in laboratory more than 48 hours after collection.

Reference Range:
See individual components.
Hepatitis Chronic B & C Panel Interpretation:
HBsAG Anti-HBc Anti-HBs Anti-HBc IgM Anti-HBe HBeAG Anti-HCV Interpretation
+ + + Chronic Type B Hepatitis, infectious state, (consider ordering HBV-DNA)
+ + + Chronic Type B Hepatitis, carrier state
+ + + not done not done Acute Type B Hepatitis
+ not done not done Past Type B Hepatitis infection, no evidence of immunity
+ + not done not done Past Type B Hepatitis infection with immunity
+/- +/- not done not done + Chronic Type C Hepatitis
not done not done not done Compatible with non-B, non-C Hepatitis
+ + + + Co-infection of Type B and Type C Hepatitis (if Type C Hepatitis is confirmed)*

*If Anti-HCV is positive, recommend performing HCV RNA Quantitative by PCR, Ultra Sensitive (40738) to determine if patient is infected with HCV.

PeaceHealth Laboratories