82700:CORTISOL, URINARY FREE, 24-HOUR URINE

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82700:CORTISOL, URINARY FREE, 24-HOUR URINE
Alias Names: Urinary Free Cortisol
Methodology: Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
Edit Date: 6/11/2010
Performed: Daily
Released: 24-48 hours after setup at PeaceHealth Laboratories’ reference lab.
CPT Code: 82530-90
Specimen Collection Details
Collection: 24-hour urine in a clean, dry plastic container. Refrigerate during collection and handling. Also acceptable: random urine.
Handling: Note total volume and time collection started and stopped.
Stability: 48 hours ambient, 14 days refrigerated, or 6 months frozen.
Standard Volume: 3 mL aliquot.
Minimum Volume: 1 mL aliquot.
Transport: Frozen on dry ice, or refrigerated at 2-8° C.
Comments: No dietary restirctions besides excessive Prednisolone medication.
Rejection Criteria: Specimen that has been preserved or acidified.

Test Name Age Female Male
Cortisol (µg/day) 3-8 years <18 µg/day <18 µg/day
9-12 years <37 µg/day <37 µg/day
13-17 years <56 µg/day <56 µg/day
≥ 18 years <45 µg/day <60 µg/day
Cortisol (µg/g crt) Prepubertal <25 µg/g crt <25 µg/g crt
≥ 18 years <45 µg/g crt <32 µg/g crt
Pregnancy <59 µg/g crt

Ratios to creatinine may be useful for evaluation when the urine collection is random, other than 24-hour, or the urine volume is less than 400 mL/24 hours.

Low urinary cortisol concentrations may be consistent with adrenal insufficiency.