81131:PARANEOPLASTIC AUTOANTIBODY EVALUATION, SERUM

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81131:PARANEOPLASTIC AUTOANTIBODY EVALUATION, SERUM
Methodology: Indirect Immunofluorescent Antibodies (IFA); Enzyme Immunoassay (EIA); Radio Immunoassay (RIA); Western Blot (WB)
Edit Date: 3/4/2008
Components: Anti-Neuronal Nuclear Ab Type 1 / Anti-Neuronal Nuclear Ab Type 2 / Anti-Neuronal Nuclear Ab Type 3 / Purkinje Cell Cytoplasmic Ab Type 1 / Purkinje Cell Cytoplasmic Ab Type 2 / Purkinje Cell Cytoplasmic Ab Type Tr / Amphiphysin Ab S / CRMP-5-IgG S / Striational (Straited Muscle) Ab S / Calcium Channel Bind Ab P/Q-Type / Calcium Channel Bind Ab N-Type / ACh Receptor (Muscle) Binding Ab. IF REFLEXED / Paraneoplastic Autoantibody Western Blot S / CRMP-5-IgG Western Blot S / GAD65 Ab Assay S / ACh Receptor (Muscle) Modulating Ab / ACh Receptor (Muscle) Blocking Ab.
Performed: Monday-Friday
Released: 7-10 days after setup at PeaceHealth Laboratories’ reference lab.
CPT Code: 83519-90 x5 / 83520-90 / 86256-90 x9
Specimen Collection Details
Collection: One 5 mL red top tube. Also acceptable: One 7.5 mL serum separator tube (SST).
Handling: Allow to clot, centrifuge and separate serum from cells and pour into a plastic vial. Refrigerate.
Standard Volume: 4 mL serum.
Minimum Volume: 2 mL serum.
Transport: Refrigerated.
Comments: Useful in the serological evaluation of patients who present with a subacute neurological disorder of undetermined etiology, especially those with known risk factors for cancer; directing a focused search for cancer; investigating neurological symptoms that appear in the course of, or after, cancer therapy, and are not explainable by metastasis; differentiating autoimmune neuropathies from neurotoxic effects of chemotherapy; monitoring the immune response of seropositive patients in the course of cancer therapy; detecting early evidence of cancer recurrence in previously seropositive patients.

Negative results do not exclude cancer.

This evaluation does not include Ma2 autoantibody (alias: MaTa) or the NMDA receptor (NR2B). Ma2 autoantibody has been described in patients with brainstem and limbic encephalitis in the context of testicular germ cell neoplasms. Scrotal ultrasound is advisable in men who present with unexplained subacute encephalitis. NMDA receptor antibodies have been reported in women with paraneoplastic encephalitis related to ovarian teratoma.

Rejection Criteria: Hemolysis for AChR Modulation Antibody.