69050:MITOCHONDRIAL ANTIBODY

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69050:MITOCHONDRIAL ANTIBODY
Alias Names: Anti-Mitochondrial
Methodology: Enzyme-Linked Immunosorbent Assay (ELISA)
Edit Date: 7/26/2006
Performed: Thursday
Released: Same day as tested
CPT Code: 83516
Specimen Collection Details
Collection: One 7.5 mL serum separator tube (SST). Also acceptable: One 5 mL red top tube.
Handling: Allow to clot 10 minutes; centrifuge and separate serum from cells immediately and pour into a plastic vial. Refrigerate. Freeze at -20° C if specimen cannot be assayed within 5 days. Avoid repeated freeze/thaw cycles.
Standard Volume: 1 mL serum.
Minimum Volume: 100 µL serum.
Transport: Refrigerated; or if frozen, on dry ice.
Rejection Criteria: Plasma; gross lipemia; hemolysis; contaminated specimen.

Mitochondrial Antibody, IgG Result Interpretation, ELISA Method:

Less than or up to 20.0 EU (EU=ELISA Unit)

Less than or up to 20.0 EU Negative: No mitochondrial antibody (AMA) detected
20.1-24.9 EU Equivocal: Repeat testing may be helpful.
At or more than 25.0 EU Positive: Mitochondrial IgG antibody (AMA) detected.

Anti-mitochondrial antibodies (AMA) have been reported in 90-95% of patients with primary biliary cirrhosis (PBC). AMA are also occasionally found in sera of patients with other liver conditions, including chronic active hepatitis, cryptogenic cirrhosis and in patients with clinical but no biochemical evidence of liver disease.