58462:HERPES SIMPLEX VIRUS (HSV) 1 GLYCOPROTEIN G-SPECIFIC, IgG

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58462:HERPES SIMPLEX VIRUS (HSV) 1 GLYCOPROTEIN G-SPECIFIC, IgG
Methodology: Multiplex flow Immunoassay (Luminex)
Edit Date: 6/11/2010
Performed: Daily
Released: Same day as tested
CPT Code: 86695
Specimen Collection Details
Collection: One 7.5 mL serum separator tube (SST). Also acceptable: One 5 mL red top tube.
Handling: Allow to clot, centrifuge and separate serum from cells immediately. Refrigerate. Freeze at -20º C if specimen cannot be assayed within 7 days. Allow no more than three freeze/thaw cycles. If multiple tests are ordered, send separate specimen for this test.
Standard Volume: 1 mL serum.
Minimum Volume: 0.5 mL serum.
Transport: Refrigerated, or frozen on dry ice.
Rejection Criteria: Plasma, grossly contaminated, hemolyzed, lipemic, heat-inactivated, or icteric specimen; refrigerated specimen received in laboratory more than 7 days after collection; specimen frozen and thawed more than three times.

Reference Range:<0.9 AI (AI = Antibody Index)
Herpes Simplex Virus (HSV) Type 1 Glycoprotein G-Specific Antibody, IgG
<0.9 AI Negative: No significant level of detectable IgG antibody to HSV type 1 glycoprotein G.
0.9-1.0 AI Equivocal: Questionable presence of IgG antibody to HSV type 1. Repeat testing in 10-14 days may be helpful.
≥ 1.1 AI Positive: IgG antibody to HSV type 1 glycoprotein G detected, which may indicate a current or recent HSV infection.
Individuals infected with HSV may not exhibit detectable IgG antibody to glycoprotein G in the early stages of infection and 5-10% of infections may occur with glycoprotein G deficient virus. Detection of antibody presence in these cases may only be possible using a non- type-specific screening test.