58459:HERPES SIMPLEX VIRUS (HSV) 1 and 2 GLYCOPROTEIN G-SPECIFIC, IgG

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58459:HERPES SIMPLEX VIRUS (HSV) 1 and 2 GLYCOPROTEIN G-SPECIFIC, IgG
Methodology: Multiplex flow immunoassay (Luminex)
Edit Date: 4/19/2010
Performed: Daily
Released: Same day as tested
CPT Code: 86695 / 86696
Specimen Collection Details
Collection: One 7.5 mL serum separator tube (SST). Also acceptable: One 5 mL red top tube.
Handling: Allow to clot10 minutes, centrifuge and immediately separate serum from cells into a plastic vial. Refrigerate. Freeze at -20° C if specimen cannot be assayed within 7 days . Allow no more than three freeze/thaw cycles. If multiple tests are ordered, send separate specimen for this test.
Standard Volume: 1 mL serum.
Minimum Volume: 0.5 mL serum.
Transport: Refrigerated, or frozen on dry ice.
Rejection Criteria: Plasma; grossly contaminated, hemolyzed, lipemic, heat-inactivated, or icteric specimen; specimen received in laboratory ambient more than 8 hours or refrigerated more than 7 days after collection; specimen frozen and thawed more than three times.

Reference Range: <0.90 AI (Antibody Index)
<0.90 AI
Negative: No significant level of detectable IgG antibody to HSV type 1 glycoprotein G.
0.90-1.10 AI
Equivocal: Questionable presence of IgG antibody to HSV type 1. Repeat testing in 10-14 days may be helpful.
>1.10 AI
Positive: IgG antibody to HSV type 1 glycoprotein G detected, which may indicate a current or recent HSV infection.
<0.90 AI
Negative: No significant level of detectable IgG antibody to HSV type 2 glycoprotein G.
0.90-1.10 AI
Equivocal: Questionable presence of IgG antibody to HSV type 2. Repeat testing in 10-14 days may be helpful.
>1.10 AI
Positive: IgG antibody to HSV type 2 glycoprotein G detected, which may indicate a current or recent HSV infection.
Individuals infected with HSV may not exhibit detectable IgG antibody to glycoprotein G in the early stages of infection and 5-10% of infections may occur with glycoprotein G deficient virus. Detection of antibody presence in these cases may only be possible using a non type-specific screening test.