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|Alias Names:||Hydroxyitracon / Hydroxyitraconazole|
|Methodology:||High Performance Liquid Chromatography (HPLC)|
|Released:||4 days after setup at PeaceHealth Laboratories’ reference lab|
|Specimen Collection Details|
|Collection:||One 5 mL red top tube. Do not use serum separator tube (SST).|
|Handling:||Allow to clot, centrifuge and separate serum from cells into a plastic vial. Freeze.|
|Standard Volume:||2 mL serum|
|Minimum Volume:||1 mL serum|
|Transport:||Frozen on dry ice.|
|Comments:||Itraconazole is an antifungal drug useful for the treatment of blastomycosis, histoplasmosis, coccidioidomycosis, sporotrichosis, ringworm, tinea versicolor, and asperfillosis, as well as therapy for oral and esophageal candidiasis (thrush). Peak plasma concentrations are attained in 1.5 to 4 hours following oral administration. Hydroxyitraconazole, a metabolite of itraconazole, appears in blood in amounts approximately twice that of the parent drug, and has antifungal activity and pharmacokinetic similar to those of the parent compound. Plasma concentrations of itraconazole measured by HPLC are thus approximately 3.5 times lower than those determined by bioassay. Levels of both itraconazole and hydroxyitraconazole are provided.|
|Rejection Criteria:||Use of SST.
This test may require insurance company prior authorization before ordering.
Please check the prior authorization list .
Failure to gain preauthorization may result in denial of coverage.