58950:VARICELLA ZOSTER VIRUS (VZV) ANTIBODY, IgG

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58950:VARICELLA ZOSTER VIRUS (VZV) ANTIBODY, IgG
Alias Names: VZV Antibody, IgG
Methodology: Enzyme-Linked Immunosorbent Assay (ELISA)
Edit Date: 4/19/2010
Performed: Tuesday, Friday
Released: Same day as tested
CPT Code: 86787
Specimen Collection Details
Collection: One 7.5 mL serum separator tube (SST). Also acceptable: One 5 mL red top tube.
Handling: Allow to clot, centrifuge and immediately separate serum from cells. Refrigerate. Freeze at -20° C if specimen cannot be assayed within 48 hours. Allow no more than one freeze/thaw cycle. If multiple tests are ordered, send separate specimen for this test.
Standard Volume: 0.5 mL serum.
Minimum Volume: 200 µL serum.
Transport: Refrigerated, or frozen on dry ice.
Rejection Criteria: Gross lipemia or gross hemolysis; heat inactivated or icteric specimen; bacterial contamination; specimen frozen and thawed more than once; refrigerated specimen received in laboratory more than 48 hours after collection.

Varicella-Zoster Virus IgG Antibody Result Interpretation, ELISA Method:

<0.9 IV

<0.9 IV Negative: No significant level of detectable Varicella-Zoster antibody; presumed non-immune to Varicella-Zoster.
0.9-1.0 IV Equivocal: Repeat testing in 10-14 days may be helpful.
>1.0 IV Positive: IgG antibody to Varicella-Zoster detected, which may indicate a current or previous Varicella-Zoster infection. Positive IgG antibody levels in the absence of current clinical symptoms may indicate immunity.
IV = Index Value

Seroconversion between acute and convalescent sera is considered strong evidence of current or recent infection. The best evidence for infection is a significant change on two appropriately timed specimens, where both tests are done in the same laboratory.