87740:RENIN ACTIVITY

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87740:RENIN ACTIVITY
Alias Names: Capoten
Methodology: Radioimmunassay (RIA)
Edit Date: 6/11/2010
Performed: Daily
Released: 24-48 hours after setup at PeaceHealth Laboratories’ reference lab.
CPT Code: 84244-90
Specimen Collection Details
Collection: One 4 mL lavender top tube (EDTA). NOTE: Specimen should be drawn between 7:00 and 10:00 a.m. If an upright sample is collected, patient should be seated upright or standing for at least two hours prior to collection. Do not refrigerate or collect in refrigerated tubes.
Handling: Centrifuge at ambient temperature and separate plasma from cells. Freeze immediately. Allow no more than one freeze/thaw cycle. If multiple tests are ordered, send separate specimen for this test.
Do not maintain EDTA lavender tube in an ice bath. Specimen should remain ambient until after centrifugation. Prorenin converts to renin at a faster rate when refrigerated, causing elevated results.
Stability: After separation from cells specimen is stable 6 hours ambient or 1 month frozen. Unstable refrigerated.
Standard Volume: 2 mL plasma.
Minimum Volume: 1.2 mL plasma.
Transport: Frozen, on dry ice.
Rejection Criteria: Specimen frozen and thawed more than once; refrigerated specimen; serum; hemolysis; heparinized, citrated, or oxalated plasma.

Plasma renin activity measures enzyme ability to convert angiotensinogen to angiotensin I and is limited by the availability of angiotensinogen. Plasma renin activity is not an accurate indicator of enzyme activity when angiotensinogen is decreased.