80520:AMINOLEVULINIC ACID (ALA), 24 HOUR URINE

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80520:AMINOLEVULINIC ACID (ALA), 24 HOUR URINE
Alias Names: ALA, URINE, 5-AMINOLEVULINIC ACID, DELTA-ALA
Methodology: Ion Exchange Chromatography/Spectrometry
Edit Date: 6/10/2010
Performed: Monday, Wednesday, Thursday, Saturday
Released: 1-4 days after setup at PeaceHealth Laboratories’ reference lab.
CPT Code: 82135-90
Specimen Collection Details
Collection: 24-hour urine. NOTE: Patient should abstain from alcohol consumption for 24 hours prior to collection. Random samples are acceptable, particularly when collected during a symptomatic episode. Samples must be refrigerated during collection, storage and transport. Protect from light during collection, storage, and transport.
Handling: Protect specimen from light. Mix well and pour off a 5 mL urine aliquot. Freeze. Record total volume of collection on tube and on requisition.
Stability: 4 days refrigerated or 1 month frozen. Specimen unstable ambient.
Standard Volume: 5 mL urine aliquot.
Minimum Volume: 1.2 mL urine aliquot.
Transport: Frozen on dry ice.
Comments: Specimen preservation with acid or base is discouraged and may cause assay interference. When collecting urine for additional tests that require acid or base preservation, the ALA aliquot should be removed prior to the addition of the acid or base.
Rejection Criteria: Ambient specimen.

Aminolevulinic Acid, Urine
0-35 umol/L
Aminolevulinic Acid, Urine, 24-hour
0-60 umol/d
Creatinine (24-hour)
Age
18-50 years 51-80 years >80 years
Male
1000-2500 mg/d 800-2100 mg/d 600-2000 mg/d
Female
700-1600 mg/d 500-1400 mg/d 400-1300 mg/d

Note: Slight elevations of ALA may be seen in association with exposure to alcohol, lead, and a variety of other agents. Significant elevations are often associated with the acute porphyrias [massive elevations of porphobilinogen (PBG)]. Significant elevations are also seen in hereditary tyrosinemia.